The Best DHT-Blocking Shampoos

If your goal is hair regrowth, chances are you’re already familiar with the relationship between DHT and hair loss. Formally known as dihydrotestosterone, this male hormone is responsible for the formation of male genitalia in the womb and the development of body hair, facial hair, and a deep voice during puberty. Unfortunately, DHT also plays a significant role in male pattern baldness. 

To mitigate these effects, many hair loss treatments aim to block DHT production. Some of these products come in the form of shampoo, and they can improve hair health while nourishing your follicles, saving your existing hair and even creating an environment to regrow thicker hair.

There’s limited research on what’s the best DHT blocker shampoo out there, so instead we’ve explored which ingredients — from shampoo with finasteride to options with pumpkin seed oil and saw palmetto — are best for combating DHT and, as a result, hair shedding.

As you may have guessed, DHT blockers combat the effects of DHT by preventing its formation. While some can do this when ingested, DHT-blocking shampoos work at the scalp level. Instead of blocking DHT throughout your body, the ingredients in DHT-blocking shampoos lower DHT activity where it matters most for hair loss — at the hair follicle.

One of the cool things about DHT-blocker shampoos is that many contain natural ingredients like pumpkin seed oil or saw palmetto. These plant-derived substances specifically target hair fall, while other ingredients promote healthy, shiny hair. We’re talking argan oil, jojoba oil, biotin, collagen, keratin, vitamin E, green tea extract, and nettle — to name just a few. 

Whether you want a hair re-growth shampoo or are looking to reduce hair fallout for healthier-looking hair, the best DHT-blocking shampoos for men can help. There are several ingredients you’ll want to look for when selecting a shampoo to stop hair loss, whether along the hairline or elsewhere, including:

• Finasteride

• Saw palmetto

• Pumpkin seed oil

• Ketoconazole

Let’s look at how each of these can help you in more detail.

Shampoo with Finasteride

One of the most well-known DHT blockers is the hair loss medication finasteride (known by its brand name Propecia®). It works by inhibiting the enzyme 5 alpha-reductase, which reduces your body’s ability to convert testosterone to DHT.

Finasteride-based DHT-blocking shampoos use the same mechanism as finasteride pills, which is well-documented after decades of use. The difference is that they work topically on the scalp, whereas the oral medication works throughout the whole body.

This means DHT-blocking shampoos are unlikely to cause the (rare) sexual side effects associated with finasteride.

Saw Palmetto Shampoo

Saw palmetto (or Serenoa repens) is a palm-like shrub that hails from the Southeastern United States. The ingredient has gained popularity as a dietary supplement that can help alleviate symptoms linked to an enlarged prostate gland, also known as benign prostatic hyperplasia (BPH).

One of the main potential benefits of saw palmetto is that it seems to reduce DHT uptake by the hair follicle. In theory, less DHT equals more hair. More research is needed on saw palmetto for hair loss, but initial findings show it’s well-tolerated. 

Our thickening shampoo with saw palmetto is an easy way to incorporate the ingredient into your everyday routine if you’re interested in giving it a try.

Pumpkin Seed Oil Shampoo

Pumpkin seeds may be a tasty fall snack, but as part of your shampoo’s ingredient list, pumpkin seed oil for hair growth may be worth having around all year.

A 2014 study found that men who took a 400-milligram pumpkin seed oil supplement daily for 24 weeks showed improvements in hair growth. On average, the supplement seemed to cause a 40 percent increase in hair count in balding men (compared to just 10 percent in the placebo group).

The study was comprehensive, but pumpkin seed oil wasn’t the only ingredient in the supplement, so it’s hard to say for sure that it was the pumpkin doing the work. The study also did not explore the effects of topical pumpkin seed oil specifically.

While the exact mechanism of how pumpkin seed oil slows hair loss isn’t totally clear, animal studies suggest it may inhibit 5α-reductase, stopping testosterone from becoming DHT.

Ketoconazole Shampoo

Ketoconazole isn’t a DHT-blocking medication, but it might be effective for helping hair growth. That’s partly because ketoconazole may help ease scalp psoriasis and get rid of dandruff (ketoconazole is an ingredient in many anti-dandruff shampoos).

Psoriasis and dandruff don’t cause hair loss per se, but all that scratching can damage the hair follicle, leaking to breakage and hair loss over time.

One older study from 1998 compared ketoconazole and the hair loss medication minoxidil (you may know it by its brand name, Rogaine®). Researchers found that 2% ketoconazole shampoo and minoxidil increased the size and proportion of anagen hair follicles at a similar rate.

So as your hair follicles shrink, you’re left with thinning hair, but ketoconazole may increase the diameter of the follicle, so each individual hair is thicker.

With this said, it’s important to note that research into ketoconazole shampoo for hair loss and its effects on scalp DHT levels is still limited. 

If you’re interested in learning more, our guide to ketoconazole and hair loss goes into further detail about recent research on ketoconazole as an active ingredient in hair loss products.

Wondering what to look for in a hair loss shampoo? Here are some factors to keep in mind when comparing shampoos designed to block DHT and prevent hair loss:

• Check the ingredients before you buy. Not all hair loss prevention shampoos contain science-backed active ingredients, so be sure to check the ingredients list before buying anything. Also note that ingredient lists are written in descending order of predominance, so a product contains the most of whichever ingredient is listed first.

• See an ambitious claim? Look for evidence. Many shampoo brands make big claims about their products’ abilities to prevent shedding, promote hair growth, and add extra volume to your hair — without providing any actual proof. If you see a shampoo that makes big promises, put in some time to research the active ingredients.

• Stick with proven, effective ingredients. Almost all ingredients used in hair loss prevention shampoos offer some benefits, whether it’s improved hair texture or just a pleasant scent. However, it’s the active ingredients that do the real work.

• Be careful of ingredients that cause irritation. Some ingredients used in shampoos may cause irritation. If you have sensitive skin, look for sulfate-free and paraben-free formulas. Our guide to sulfates in shampoo talks more about the effects of sulfates, as well as the steps you can take to avoid them if you have sensitive skin.

• When it comes to shampoo for thinning hair, don’t associate cost with effectiveness. Many great hair loss shampoos are affordable. When comparing shampoos, look for active ingredients, not a high price tag. Many of the best DHT-blocking shampoos are budget-friendly.

• Use a DHT shampoo alongside a hair loss medication. While the right shampoo can help prevent hair loss by itself, you’ll get the best results by combining it with science-based hair loss treatments, such as finasteride and minoxidil. These medications work to block DHT and promote hair growth.

• Check customer reviews before you buy. Like other hair care products, DHT-blocker shampoos can vary in quality and effectiveness. If you’re shopping online, read reviews from previous customers before committing to a product.

• Don’t forget to use a conditioner or buy a conditioner set. Conditioner helps strengthen your hair and give it extra shine and moisture. Applying conditioner is particularly important if you have a hair type that gets dry or damaged easily. Our Thick Fix conditioner with niacinamide is formulated to support healthy hair growth while helping your hair appear thicker and fuller.

• Have realistic expectations. Though many ingredients used in DHT-blocking shampoos are supported by scientific evidence, none should be viewed as alternatives to or replacements for FDA-approved hair loss medications. While the right shampoo may help stimulate hair growth, it’s unlikely to completely turn around hair loss on its own. It may take a few months before you notice a change, too.

DHT-blocker shampoo side effects are usually minimal, especially if you don’t have a sensitive scalp, but there are some side effects of these cleansing products to watch out for

Potential DHT-blocking shampoo side effects include:

• Dryness and itching. Dryness and itching aren’t associated with DHT-blocking shampoos specifically. But if the shampoo contains sulfates (often listed as sodium lauryl sulfate or SLS), you may experience these side effects.

• Fading colored hair. Yep, sulfates again. They’re often added to shampoos to get it to foam and lather, but they can be harsh, leading to fading if you have color-treated hair.

• Unwanted hair growth. If your DHT-blocking shampoo contains minoxidil as a key ingredient, make sure you’re applying it carefully and as directed. And be on the lookout for unwanted hair growth on other parts of your body.

• Skin irritation. Natural DHT blockers may contain other natural ingredients that may help fight hair loss and increase thickness, like lavender, peppermint, tea tree oil, or rosemary oil. While these are generally safe to use for most people, some might experience redness or irritation.

If you had a reaction to a new haircare product before, you’re wise to do a patch test first. Rub a small amount of product onto the back of your forearm and wait to see if a reaction develops.

A DHT shampoo certainly deserves a spot in your shower (if you can find one, depending on who you live with). But to tackle hair loss from multiple angles, consider pairing hair loss medications and treatments with your new suds-ing routine.

Minoxidil

Incorporating minoxidil into your routine can help with hair loss. Minoxidil is a vasodilator, meaning it dilates blood vessels, bringing blood, oxygen, and nutrients to the scalp. It was originally used to treat high blood pressure, but researchers noticed that it had a pleasant but unintended side effect of hair growth.

Minoxidil is approved for men and women, whereas finasteride is only FDA-approved for men at this time.

Currently, we offer a topical minoxidil foam and a liquid minoxidil solution (both at 5% strength). They work the same way and are applied directly to the scalp. Some people with longer hair may think the liquid solution is easier to apply since it has a dropper. 

Although rare, some people experience redness and irritation where they apply minoxidil. It’s unclear why this happens, but some researchers think the reaction may be caused by propylene glycol. The foam doesn’t contain this ingredient, so it’s a good choice for sensitive skin or if you’ve tried minoxidil before and had a reaction.

Finasteride

Finasteride is a prescription medication that stops the conversion of testosterone to DHT. While all men have DHT, not all men lose their hair. This is because some are more sensitive to the hormone than others. 

Finasteride can be taken any time of day (as long as you’re consistent from day to day) with or without food.

Minoxidil and Finasteride Together

A 2019 meta-analysis looked at the efficacy of minoxidil and finasteride for hair loss. It found that the combo of finasteride and topical minoxidil is more effective and just as safe as using one or the other on its own.

Worried about adding another step to your routine or having more products cluttering up your bathroom? Our topical finasteride & minoxidil spray makes it easy to apply both at the same time.

Other Natural Ingredients

You might also find benefits by pairing other natural ingredients with a DHT-blocking shampoo.We mentioned peppermint and lavender oils already as two promising options. 

One review shows that rosemary helps regenerate hair follicles in a similar way to minoxidil. So you might look for a shampoo that pairs ingredients that inhibit 5-alpha-reductase (pumpkin seed, saw palmetto, and green tea) with rosemary.

For men experiencing male pattern baldness (also known as androgenic alopecia) or another form of hair loss, incorporating DHT-blockers into your shampooing routine can be a great option. You just need to make sure you’re purchasing the right products and using them correctly.

Here’s a quick cheat sheet to screenshot before you shop:

• When comparing anti-DHT shampoos, look for products that use proven ingredients like saw palmetto or pumpkin seed oil. These substances have been shown to block DHT from getting into the hair follicle.

• DHT-blocking shampoos will only work if your hair loss is caused by DHT. If you’re losing hair from stress or a lack of nutrients, try a biotin shampoo or a volumizing shampoo and volumizing conditioner, which can make hair stronger and fuller-looking.

• Expensive doesn’t equal better when it comes to hair loss shampoos (and most things, TBH). Before you assume something works well because of its high price tag, check the active ingredients.

Still have questions? Ask a dermatologist what anti-hair loss shampoo or treatment is best for your specific situation.

Don’t want to make an in-person appointment? You can also take our hair loss quiz to determine your specific hair loss needs and connect with an online healthcare professional who can help.